The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects

详细信息    查看全文

• 作者：Mei Yang^a ; Vasish Kavi^a ; Wenfu Wang^b ; Zhimei Wu^b ; Wei Hao^a ; ^{weihao57@gmail.com}
• 关键词：APSD ; antisocial personality disorder ; bp ; base-pair ; COMT ; catechol-O-methyltransferase gene ; DA ; dopamine ; DAT ; dopamine transporter gene ; 5-HT ; 5-hydroxytryptamine or serotonin ; 5-HTR2A ; 5-hydroxytryptamine receptor 2A gene ; 5-HTT ; 5-hydroxytryptamine
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2012
• 出版时间：30 March 2012
• 年：2012
• 卷：36
• 期：2
• 页码：282-289
• 全文大小：404 K

文摘

Objective

To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with comorbidity of antisocial personality disorder in male heroin-dependent patients.

Subjects and methods

In case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 588 male heroin-dependent patients (including 311 patients with antisocial personality disorder and 277 patients without antisocial personality disorder) and 194 normal males by genotypes, alleles, and interaction between genes.

Results

Between male heroin-dependent patients with antisocial personality disorder and normal males, and between male heroin-dependent patients with and without antisocial personality disorder, the distributions of 5-HTTVNTR polymorphic genotypes and alleles were in statistical significance. Individuals carrying 10R allele were in higher risk of the comorbidity of antisocial personality disorder and heroin dependence. By MDR analyses, the interaction between 5-HTTVNTR and DATVNTR was close to statistical significance in predicting the risk of antisocial personality disorder in male heroin dependent patients. In male heroin dependent patients, individuals carrying 5-HTTVNTR 10R allele or/and DATVNTR 9R allele were in higher risks of co-occurring antisocial personality disorder, while individuals with 5-HTTVNTR 12R/12R and DATVNTR 10R/10R genotypes together were in lower risks of antisocial personality disorder.

Conclusion

5-HTTVNTR, and the interaction between 5-HTTVNTR and DATVNTR may be associated with the comorbidity of antisocial personality disorder in male heroin-dependent patients.