Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice
详细信息 查看全文
- 作者：Vera L. Bonilhaa ; b ; bonilhav@ccf.org" class="auth_mail" title="E-mail the corresponding author ; Brent A. Bellb ; Mary E. Raybornb ; Xiaoping Yangb ; Charlie Kaulb ; Gregory H. Grossmanb ; 1 ; Ivy S. Samuelsb ; c ; Joe G. Hollyfielda ; b ; Chengsong Xied ; Huaibin Caid ; Karen G. Shadrachb
- 关键词：DJ-1 knockout ; Retina ; Morphology ; Physiology ; Histology ; Immunohistology ; Biochemistry ; Oxidation
- 刊名：Experimental Eye Research
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：139
- 期：Complete
- 页码：22-36
- 全文大小：6162 K
文摘
- •
First report of the visual defects due to the absence of DJ-1 expression in mice retinas.
- •
DJ-1 KO mice displayed increased b-wave amplitude and cone ERGs, and decreased dc-ERG amplitude.
- •
DJ-1 KO retinas displayed structural changes in the outer plexiform layer, photoreceptors and retinal pigment epithelium.
- •
DJ-1-deficient retinas changes are associated with increased oxidative stress.