Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair
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- 作者：Hualin Zhanga ; zhanghualin303@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhong Lib ; Zhongli605@126.com" class="auth_mail" title="E-mail the corresponding author ; Zhongliu Zhoua ; Hongyan Yanga ; Zhiyong Zhongc ; Caixia Louc
- 关键词：Ginsenoside ; Antidepressant ; Monoamine neurotransmitters ; HPA ; Mice
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：17-26
- 全文大小：1686 K
文摘
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The antidepressant effects of ginsenoside Rb3 and Rg3, Rh2, C-K, and PPD were compared.
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C-K showed similar activities to Rb3, whereas Rg3 had better effects than Rb3.
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Rg3, C-K and Rb3 increased the NA levels in the brain regions of mice.
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Rg3 reversed stress-induced increase in the levels of serum ACTH and corticosterone.