The inhibition of spinal synaptic plasticity mediated by activation of AMP-activated protein kinase signaling alleviates the acute pain induced by oxaliplatin
The decreased AMPKα via enhancing spinal synaptic plasticity contributed to the acute pain following single intraperitoneal injection of oxaliplatin. Activation of mTOR/p70S6K signal pathway contributed to acute pain induced by low concentration of oxaliplatin entering CNS. The decreased AMPKα via negatively regulating the mTOR/p70S6K signal pathway mediated the acute pain induced by oxaliplatin.