文摘
Human ApoE robustly stimulates APP transcription and Aβ production in human neurons ApoE4 is more potent and ApoE2 less potent than ApoE3 in stimulating Aβ production ApoE activates a non-canonical MAP kinase pathway involving DLK, MKK7, and ERK1/2 ApoE-activated MAP kinases phosphorylate cFos to induce APP and Aβ production