2,5-Deoxyfructosazine, a d-glucosamine derivative, inhibits T-cell interleukin-2 production better than d-glucosamine

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• 作者：Aiping Zhu ; Ji-Biao Huang ; Andrea Clark ; Roberto Romero ; Howard R. Petty
• 关键词：Immune cell ; Cytokine release ; d-Glucosamine ; Fructosazine
• 刊名：Carbohydrate Research
• 出版年：2007
• 出版时间：28 December 2007
• 年：2007
• 卷：342
• 期：18
• 页码：2745-2749
• 全文大小：363 K

文摘

d-Glucosamine has been widely reported to have immunosuppressive actions on neutrophils, lymphocytes, and other cells of the immune system. However, under conditions used in biological experiments (e.g., neutral pH, and phosphate buffers), we have found that d-glucosamine self-reacts to form 2,5-deoxyfructosazine [2-(d-arabino-tetrahydroxybutyl)-5-(d-erythro-2,3,4-trihydroxybutyl)pyrazine] (1) and 2,5-fructosazine [2,5-bis(d-arabino-tetrahydroxybutyl)pyrazine] (2). When tested for bioactivity at nontoxic concentrations, these d-glucosamine derivatives were more effective inhibitors of IL-2 release from PHA-activated T cells than d-glucosamine. Hence, fructosazines constitute a novel class of immunomodulators.