The source of Mycobacterium tuberculosis-specific IFN-γ production in peripheral blood mononuclear cells of TB patients
详细信息 查看全文
- 作者：Feng Wang ; Lie Mao ; Hongyan Hou ; Shiji Wu ; Min Huang ; Botao Yin ; Jing Huang ; Qin Zhu ; Yingying Pan ; Ziyong Sun ; zysun@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tuberculosis ; IFN-γ ; CD4+ T cells ; CD8+ T cells ; NK cells
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：39-45
- 全文大小：1593 K
文摘
- •
CD4+, CD8+ T cells and NK cells are all major Mtb-specific IFN-γ producers in TB.
- •
CD8+ T cells are the most Mtb-specific IFN-γ-producing cells in HIV/TB patients.
- •
Mtb-specific antigen stimulation in vitro increases NK cell activity of TB patients.
- •
CD45RO is the characteristic marker of Mtb-specific IFN-γ-producing T cells.
- •
Mtb-specific IFN-γ-producing NK cells have a high expression of CD11a.