Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses
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- 作者：Wei-Bei Wang1 ; 8 ; Men-Luh Yen2 ; 8 ; Ko-Jiunn Liu3 ; 4 ; kojiunn@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author ; Pei-Ju Hsu1 ; Ming-Hong Lin5 ; Pei-Min Chen2 ; Putty-Reddy Sudhir6 ; Chein-Hung Chen6 ; Chung-Hsuan Chen6 ; Huei-Kang Sytwu5 ; B. Linju Yen1 ; 7 ; blyen@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：5
- 期：3
- 页码：392-404
- 全文大小：2447 K
文摘
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hMSC-secreted IL-25 suppress Th17 responses in vitro and in vivo
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IL-25 alone is insufficient to significantly suppress Th17 responses
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IL-25 upregulates PD-L1 expression in hMSCs to suppress Th17 cells
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IL-25-mediated PD-L1 expression can be driven by STAT3