- 作者：Cheng-Mei Yang ; Hung-Chih Chen ; Yu-Yi Hou ; Ming-Chien Lee ; Huei-Han Liou ; Sin-Jhih Huang ; Liang-Ming Yen ; Dong-Mei Eng ; Yao-Dung Hsieh ; Luo-Ping Ger
- 关键词：Oral cancer ; Pharyngeal cancer ; Polymorphisms ; Interleukin-4 ; Risk factor ; Prognostic factor
- 刊名：Archives of Oral Biology
- 出版年：January, 2014
- 年：2014
- 卷：59
- 期：1
- 页码：35-46
- 全文大小：464 K
Objective
Interleukin (IL)-4 is a key cytokine in humoral and adaptive immunity. This study aimed to evaluate the association of IL-4 genetic variants (鈭?90C>T and VNTR in intron 3) with the risk and prognosis of oral and pharyngeal squamous cell carcinoma (OPSCC).Design
A total of 1215 subjects, which included 623 healthy controls and 592 OPSCC cases (463 oral squamous cell carcinoma (OSCC) and 129 pharyngeal squamous cell carcinoma (PSCC) cases), were recruited. The genotypes were determined by TaqMan real-time assay and PCR-based assay.
Results
The IL-4 genotypes at locus 鈭?90C>T and intron 3 VNTR were not correlated with increased risk of OSCC, PSCC, and OPSCC, with the exception of early-stage OPSCC (at 鈭?90C>T: T/T vs. C/C+C/T, adjusted odds ratio (AOR) = 1.42, 95% CI: 1.02-1.98; at intron 3 VNTR: RP1/RP1 vs. RP2/RP2+RP2/RP1, AOR = 1.46, 95% CI: 1.05-2.04). Compared with other IL-4 diplotypes, the T,RP1/T,RP1 diplotype was associated with an increased risk of OPSCC (AOR = 1.37, 95% CI: 1.03-1.81), particularly early-stage OSCC (AOR = 1.43, 95% CI: 1.02-2.00), PSCC (AOR = 2.35, 95% CI: 1.06-5.19), and OPSCC (AOR = 1.52, 95% CI: 1.10-2.11). Interactions between the IL-4 diplotype and the alcohol drinking status were found to contribute to the risk of early-stage OPSCC (p = 0.024). In addition, the T,RP1/T,RP1 diplotype was correlated with better disease-specific survival (T,RP1/T,RP1 vs. other diplotypes, adjusted hazard ratio = 0.70, 95% CI: 0.50-0.97).
Conclusion
The T, RP1/T, RP1 diplotype of IL-4 was associated with an increased risk but favourable prognosis of OPSCC.