Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation

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• 作者：Anna S. Urrila ; Antti Hakkarainen ; Sami Heikkinen ; Outi Huhdankoski ; Tuomo Kuusi ; Dag Stenberg ; Anna-Maija Hä ; kkinen ; Tarja Porkka-Heiskanen and Nina Lundbom
• 刊名：Psychiatry Research: Neuroimaging
• 出版年：2006
• 出版时间：30 June 2006
• 年：2006
• 卷：147
• 期：1
• 页码：41-46
• 全文大小：160 K

文摘

Proton magnetic resonance spectroscopy (¹H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use ¹H MRS to assess the effects of specific short-term physiological states on major metabolites. Eight healthy women underwent ¹H MRS at the beginning and end of a 40-h period of sleep deprivation. The ratios of N-acetyl-aspartate (NAA), total creatine (tCr), and choline-containing compounds (Cho) to water (H₂O) were determined from the occipital cortex during both baseline and photic stimulation conditions. During sleep deprivation, NAA/H₂O decreased by 7 % and Cho/H₂O by 12 % . Photic stimulation had no effect on the measured metabolites in the alert state, but in the sleep-deprived state the level of Cho/H₂O increased during neuronal activation. The results suggest that NAA/H₂O and Cho/H₂O may depend on the state of alertness.