Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance

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• 作者：Hongbin Chen^a ; ¹ ; Zhujia Xiong^b ; ¹ ; Kuoyue Liu^c ; ¹ ; ² ; Shuguang Li^a ; Ruobing Wang^a ; Xiaojuan Wang^a ; Yawei Zhang^a ; Hui Wang^a ; ^{whuibj@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：VraSR ; Low-level vancomycin resistance ; RNA-Seq ; Staphylococcus aureus
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：47
• 期：5
• 页码：362-367
• 全文大小：1361 K

文摘

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d="par0005">Compared with vancomycin-susceptible strains, expression of m>vraSm> was upregulated in all four isogenic heterogeneous vancomycin-intermediate m>Staphylococcus aureusm> (hVISA) strains.

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d="par0010">Vancomycin MICs in the m>vraSRm> null mutants B6D-Δm>vraSRm> and D7-Δm>vraSRm> were significantly lower than in the wild-type strains B6D and D7 and the complemented strain B6D_c.

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d="par0015">RNA-Seq and qRT-PCR data showed that most of the differentially expressed proteins, including PrsA, FmtA, glycosyltransferase and TcaA, are involved in cell wall biosynthesis, which is associated with vancomycin resistance in m>S. aureusm>.

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