Design, synthesis and evaluation of multi-functional tLyP-1-hyaluronic acid-paclitaxel conjugate endowed with broad anticancer scope
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- 作者：Weiqin Wanga ; wangwq1203@163.com" class="auth_mail" title="E-mail the corresponding author ; Mengying Lia ; Zhenhai Zhangb ; Changchang Cuia ; Jianping Zhoua ; Lifang Yina ; Huixia Lva ; lvhuixia@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Paclitaxel ; Hyaluronic acid ; tLyP-1 ; CD44 receptor ; NRP1 receptor ; Tumor targeting
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：97-107
- 全文大小：2521 K
文摘
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Good solubility and stability of HA-PTX was obtained by one step method of directly linking the PTX to HA via the ester bond.
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The tLyP-1 was used to modify HA-PTX and guided the formed conjugate to penetrate multiple bio-barriers into tumor cells.
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The tLyP-1 expanded the anticancer scope of tLyP-1-HA-PTX from tumor cells expressing CD44 to those of expressing NRP1.
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Good stability and safety of conjugates were proved via FT-IR, 1H NMR, in vitro stability studies and hemolysis test.
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Enhanced targeting and accumulation of conjugates were certified by in vitro cellular uptake studies.