Reduced femoral bone mass in both diet-induced and genetic hyperlipidemia mice
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- 作者：Xiang Chena ; 1 ; Chunyu Wanga ; 1 ; Kun Zhanga ; Ying Xiea ; Xiao Jia ; Hui Huangb ; Xijie Yua ;
- 关键词：BMD ; bone mineral density ; BMSC ; Bone marrow stromal cell ; Col1a1 ; collagen type 1 alpha-1 ; CTSK ; cathepsin K ; CTx ; cross-linked type I collagen ; HDL ; high density lipoprotein ; HFD ; high-fat diet ; LDL ; low density lipoprotein ; LDLR&minus ; /&minus ; Low-density lipoprotein receptor-knockout ; LRP ; low-density lipoprotein receptor-related protein ; uCT ; microCT ; MMP9 ; matrix metallopeptidase 9 ; NFATc1 ; Nuclear factor-activated T cells c1 ; NHANES ; National Health and Nutritional Examination Survey ; OC
- 刊名：Bone
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：104-112
- 全文大小：1225 K
文摘
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Femoral bone mass was reduced in both diet-induced and genetic hyperlipidemia mice.
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Hyperlipidemia decreased osteoblastic functions and increased osteoclastic functions.
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Plasma S1P was positively associated with plasma CTx levels.
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Bone marrow cells from LDLR−/− mice showed increased adipogenesis and inhibited osteogenesis.