Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
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- 作者：Sathidpak Nantasanti1 ; Bart Spee1 ; Hedwig S. Kruitwagen1 ; Chen Chen1 ; 2 ; Niels Geijsen1 ; 2 ; Loes A. Oosterhoff1 ; Monique E. van Wolferen1 ; Nicolas Pelaez1 ; Hille Fieten1 ; Richard W. Wubbolts3 ; Guy C. Grinwis4 ; Jefferson Chan5 ; Meritxell Huch2 ; 7 ; Robert R.G. Vries2 ; Hans Clevers2 ; Alain de Bruin4 ; 6 ; Jan Rothuizen1 ; Louis C. Penning1 ; Baukje A. Schotanus1 ; b.a.schotanus@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：5
- 期：5
- 页码：895-907
- 全文大小：3109 K
文摘
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Canine hepatic organoids can be grown long term with chromosomal stability
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Organoids can be derived from liver tissues as small as fine-needle biopsies
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Differentiation and proliferation of canine organoids involve Wnt and Notch
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Successful gene supplementation proves potential for stem cell-based gene therapy