Neonatal respiratory mechanics and development of bronchial hyperresponsiveness in preterm infants

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• 作者：Snepvangers ; Yvonne ; Peter de Winter ; J. ; Burger ; Huibert ; Brouwers ; Hens ; Van der Ent ; Cornelis K.
• 关键词：Respiratory system compliance ; Respiratory system resistance ; Mechanical ventilation ; Follow-up studies ; Lung maturation ; BHR ; bronchial hyperresponsiveness ; Crs ; respiratory system compliance ; Rrs ; respiratory system resistance ; CLD ; chronic lung disease
• 刊名：Early Human Development
• 出版年：2004
• 出版时间：July, 2004
• 年：2004
• 卷：78
• 期：2
• 页码：105-118
• 全文大小：310 K

文摘

Background: In preterm ventilated infants, irreversible damage to the airway mucosa in the neonatal period might be related to the development of bronchial hyperresponsiveness (BHR) in subsequent years. Aims: To evaluate whether neonatal indicators of long-term respiratory morbidity, respiratory system compliance (Crs) and resistance (Rrs), were causally related to bronchial responsiveness at the age of 2 and whether these relationships were affected by other factors. Study design: Mean neonatal Crs and Rrs of the first 3 days of life were assessed using the single breath occlusion technique. Bronchial challenge tests were performed at 2 years of age. When wheezing occurred during chest auscultation or oxygen saturation decreased below 90 % , the provocative concentration of methacholine was recorded. Subjects: Forty-five preterm infants of <37 weeks gestation, being mechanically ventilated within 24 h after birth. Results: Decreased neonatal Crs was related to BHR (β per ml/kPa, 0.061; 95 % confidence interval, 0.019 to 0.103; p