Long-term response to successful acute pharmacological treatment of psychotic depression

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• 作者：Jaap Wijkstra ; Huibert Burger ; Walter W. van den Broek ; Tom K. Birkenhä ; ger ; Joost G.E. Janzing ; Marco P.M. Boks ; Jan A. Bruijn ; Marc L.M. van der Loos ; Leonie M.T. Breteler ; Robbert J. Verkes ; Wi
• 刊名：Journal of Affective Disorders
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：123
• 期：1-3
• 页码：238-242
• 全文大小：170 K

文摘

Background

Data about follow-up after acute pharmacological treatment of psychotic depression are scarce.

Methods

A 4 month open follow-up was done, preferentially with same medication as during acute treatment, of patients (n = 59) with DSM-IV-TR major depressive disorder with psychotic features, aged 18 to 65 years, who had completed as responders an acute double-blind 7 week trial with imipramine, venlafaxine or venlafaxine plus quetiapine. Main outcome measures were Hamilton Rating Scale for Depression and Clinical Global Impression Scale.

Results

Six patients dropped out during the 4 month follow-up. Almost all patients (86.4 % ; 51/59) remained responder while remission rate increased from 59.3 % (35/59) to 86.8 % (46/53), independent of treatment. Relapse rate was low (3.8 % ; 2/53). Tolerability was good. Weight increased with all treatments.

Limitations

Limitations were the limited sample size and consequent limited statistical power. The treatment during follow-up was not double-blind.

Conclusions

Continuation treatment with the same medication that was effective in the acute treatment trial, remained effective during the 4 month follow-up in many patients leading to further improvement, and was well tolerated.