VIP and PACAP down-regulate CXCL10 (IP-10) and up-regulate CCL22 (MDC) in spleen cells
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- 作者：Jiang ; Xiuju ; Jing ; Huie ; Ganea ; Doina
- 关键词：Neuropeptides ; Chemokines ; Dendritic cells ; Macrophages ; Th1/Th2 chemoattractants ; CK ; chemokine ; CK-R ; chemokine receptor ; IP-10 ; interferon-γ ; -induced protein 10 ; MDC ; macrophage-derived chemokine ; PACAP ; pituitary adenylate cyclase-activating polyp
- 刊名：Journal of Neuroimmunology
- 出版年：2002
- 出版时间：December, 2002
- 年：2002
- 卷：133
- 期：1-2
- 页码：81-94
- 全文大小：905 K
文摘
The immunoregulatory neuropeptides VIP and PACAP favor Th2-type immune responses. Antigen-stimulated Th2 cells produce VIP, VIP/PACAP induce Th2 cytokine responses, and promote the preferential survival of Th2 effectors. In this study, we investigate the effects of VIP/PACAP on two chemokines, i.e. CXCL10 (IP-10) acting on CXCR3 expressed on activated Th1 cells, and CCL22 (MDC) acting on CCR4 and 8 expressed on activated Th2 cells. VIP and PACAP down-regulate CXCL10, and up-regulate CCL22 in vivo and in vitro. The effects on the two chemokines appear to be different in mechanistic terms. The fact that VIP/PACAP might promote the directed migration of Th2 cells adds a new dimension to their participation in the Th2 auto-regulatory loop.