BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice
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- 作者：Jing Wua ; b ; Mingqiang Zhangb ; Huihui Lia ; Xiaoru Sunb ; Shuangying Haoa ; Muhuo Jib ; Jianjun Yangb ; yjyangjj@126.com" class="auth_mail" title="E-mail the corresponding author ; Kuanyu Lia ; likuanyu@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anesthesia ; Cognitive deficits ; Mitochondria ; Brain-derived neurotrophic factor ; Synaptic plasticity ; Aging
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：115-121
- 全文大小：1533 K
文摘
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Mitochondrion-targeted peptide SS-31 reversed anesthesia-induced mitochondrial dysfunction.
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SS-31 enhanced anesthesia-induced BDNF signaling pathway and synaptic plasticity.
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SS-31 prevented anesthesia-induced cognitive deficits.