Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells
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- 作者：Chuangyu Wena ; b ; c ; Junxiong Chena ; Di Zhanga ; Huihui Wanga ; b ; c ; Jia Chea ; b ; c ; Qiyuan Qina ; Lu Hea ; Zerong Caia ; Mengmeng Lina ; Qiong Loua ; b ; c ; Lanlan Huanga ; Daici Chena ; Aikichi Iwamotod ; 1 ; Donglin Rena ; Lei Wanga ; Ping Lana ; Jianping Wanga ; Huanliang Liua ; b ; c ; liuhuanl@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiangling Yanga ; yangxl28@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudolaric acid B ; Colorectal cancer ; 5-FU resistance ; Mitotic arrest ; Apoptosis ; Spindle
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 December 2016
- 年：2016
- 卷：383
- 期：2
- 页码：295-308
- 全文大小：6012 K
文摘
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PAB induces mitotic arrest followed by caspase-dependent apoptosis in CRC cells.
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PAB interferes with CRC cell mitotic spindle apparatus and activates the SAC.
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CDK1 activity is involved in PAB-induced mitotic arrest and apoptosis in CRC cells.
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PAB can circumvent 5-FU resistance in CRC cells.