Metabolic network destruction: Relating topology to robustness

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• 作者：Wynand  ; Winterbach^a ;   ; ^b ;   ; ^{w.winterbach@tudelft.nl} ; Huijuan  ; Wang^b ;   ; ^{h.wang@tudelft.nl} ; Marcel  ; Reinders^a ;   ; ^{m.j.t.reinders@tudelft.nl} ; Piet  ; Van Mieghem^b ;   ; ^{p.f.a.vanmieghem@tudelft.nl} ; Dick  ; de Ridder^a ;   ; ^{d.deridder@tudelft.nl}[Author vitae]
• 关键词：Metabolic networks ; Flux balance analysis ; Network topology ; Robustness
• 刊名：Nano Communication Networks
• 出版年：2011
• 出版时间：June-September 2011
• 年：2011
• 卷：2
• 期：2-3
• 页码：88-98
• 全文大小：918 K

文摘

Biological networks exhibit intriguing topological properties such as small-worldness. In this paper, we investigate whether the topology of a particular type of biological network, a metabolic network, is related to its robustness. We do so by perturbing a metabolic system in silico, one reaction at a time and studying the correlations between growth, as predicted by flux balance analysis, and a number of topological metrics, as computed from three network representations of the metabolic system.

We find that a small number of metrics correlate with growth and that only one of the network representations stands out in terms of correlated metrics. The most correlated metrics point to the importance of hub nodes in this network, so-called ¡°currency metabolites? Since they are responsible for interconnecting distant functional modules in the network, they are important points in the network for predicting if reaction removal affects growth. A second set of correlations in contrast is related to ¡°loner?nodes that uniquely connect important pathways and thus correspond to essential steps in metabolism.