Evaluation of 13C- and 2H-labeled internal standards for the determination of amphetamines in biological samples, by reversed-phase ultra-high performance liquid chromatography-tandem mass spectrometry
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- 作者：Thomas Berga ; thomas.berg@fhi.no" class="auth_mail ; Morten Karlsenb ; Å ; se Marit Leere Ø ; iestada ; Jon Eigill Johansenb ; Huiling Liub ; Dag Helge Stranda
- 关键词：13C ; Stable isotope-labeled internal standard ; LC&ndash ; MS/MS ; Isotope effect ; Deuterium ; Amphetamine
- 刊名：Journal of Chromatography A
- 出版年：30 May 2014
- 年：2014
- 卷：1344
- 期：Complete
- 页码：83-90
- 全文大小：2123 K
文摘
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Several new 13C labeled internal standards (ISs) used for the first time as ISs.
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13C labeled ISs better suited than 2H labeled ISs in RP LC–MS/MS analysis.
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13C labeled ISs behave as their analytes in chromatographic separations.
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ISs with few 2H are better suited than those with many 2H substitutes.
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No differences between extraction recovery of 13C- and 2H ISs were observed.