Evaluation of the immunogenicity of ALDHhigh human head and neck squamous cell carcinoma cancer stem cells in vitro
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- 作者：Mark E.P. Princea ; 1 ; Li Zhoua ; b ; 1 ; Jeffrey S. Moyera ; 1 ; Huimin Taoa ; c ; 2 ; Lin Lua ; d ; John Owena ; Martin Egentia ; Fang Zhenga ; c ; Alfred E. Changa ; Jianchuan Xiad ; Gregory Wolfa ; Max S. Wichaa ; Shiang Huangc ; Xiubao Renb ; renxiubao@tjmuch.com" class="auth_mail" title="E-mail the corresponding author ; Qiao Lia ; qiaoli@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Head and neck squamous cell carcinoma (HNSCC) ; Cancer stem cells (CSC) ; Aldehyde dehydrogenase (ALDH) ; Dendritic cells (DC) ; T cells ; B cells ; Antibody
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：30-42
- 全文大小：3143 K
文摘
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CSC-DC vaccine-sensitized HNSCC patient PBMC T cells produce IFNγ against CSCs.
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CSC-DC vaccine-sensitized patient CTLs lyses autologous CSCs.
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CSC-DC vaccine-sensitized patient PBMC B cells produce antibody which binds to CSCs.
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We show that the immunogenicity of HNSCC CSC is distinct from that of non-CSCs.
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Our results suggest the existence of unique CSC antigens in the ALDHhigh HNSCC cells.