Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1¦Á and Bcl-2, down-regulated Bax, NF-¦ÊB expression
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- 作者：Chaohui Wang ; Zhihong Wang ; Xiangjian Zhang ; Xiaolin Zhang ; Lipeng Dong ; Yinxue Xing ; Yanhua Li ; Zongjie Liu ; Linyu Chen ; Huimin Qiao ; Lina Wang ; Chunhua Zhu
- 关键词：Cerebral ischemia ; Protection ; Silibinin ; Akt/mTOR signaling ; Bax ; NF-¦ÊB
- 刊名：Neuroscience Letters
- 出版年：2012
- 出版时间：31 October, 2012
- 年：2012
- 卷：529
- 期：1
- 页码：45-50
- 全文大小：1335 K
文摘
Inflammation and apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Silibinin has been proved to elicit a variety of biological effects through its anti-inflammatory and anti-apoptotic properties in hepatotoxic, cancer and carcinogenic events. Whether this protective effect applies to ischemic injury in brain is still unknown, we therefore investigated the potential protective role of silibinin in ischemic stroke and the underlying mechanisms. Silibinin was administered intragastric 30 min before permanent middle cerebral artery occlusion (pMCAO). We found that silibinin significantly alleviated neurological deficit, reduced infarct volume, and suppressed brain edema, which were accompanied with upregulation of pAkt, pmTOR, HIF-1¦Á, Bcl-2 and downregulation of Bax, NF-¦ÊB in ischemic brain tissue after stroke. Our results show that silibinin might exert anti-inflammatory and anti-apoptotic effects in ischemic brain through activating Akt/mTOR signaling.