Facile one-pot synthesis of l-proline-stabilized fluorescent gold nanoclusters and its application as sensing probes for serum iron

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• 作者：Xiaoyu Mu ; Li Qi ; Ping Dong ; Juan Qiao ; Jian Hou ; Zongxiu Nie ; Huimin Ma
• 关键词：l-proline ; Gold nanocluster ; Fluorescence ; Ferric ion ; Serum iron
• 刊名：Biosensors and Bioelectronics
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：49
• 期：Complete
• 页码：249-255
• 全文大小：2046 K

文摘

Gold nanoclusters (Au NCs) possess outstanding physical and chemical attributes that make them excellent scaffolds for the construction of novel chemical and biological sensors. In this study, a simple one-pot synthesis method, employing l-proline as the stabilizer, was presented for preparation of fluorescent Au NCs. This strategy allowed the generation of water-soluble Au NCs within a short time of 15 min. The as-prepared Au NCs exhibited a bluish fluorescence emission at 440 nm and a quantum yield of 2.94 % . Based on the aggregation-induced fluorescence quenching mechanism, the Au NCs provided favorable biocompatibility, high sensitivity and good selectivity for the measurement of ferric ion (Fe³⁺). Furthermore, serum samples were analyzed for the serum iron contents by using this proposed biocompatible fluorescent sensor, indicating the potential value of this Au NCs-based fluorescent sensor for application in biological and clinical analysis.