Triblock copolymers encapsulated poly (aryl benzyl ether) dendrimer zinc(II) phthalocyanine nanoparticles for enhancement in vitro photodynamic efficacy

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• 作者：Yide Huang^c ; ¹ ; Huizhen Yu^b ; ¹ ; Huafei Lv^a ; ¹ ; Hong Zhang^a ; Dongdong Ma^a ; Hongqin Yang^d ; Shusen Xie^d ; Yiru Peng^a ; ^{yirupeng@fjnu.edu.cn}
• 关键词：Photodynamic therapy ; Dendrimer phthalocyanine ; Triblock compolymer ; Nanoparticle
• 刊名：Photodiagnosis and Photodynamic Therapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：Complete
• 页码：124-131
• 全文大小：2220 K
• 卷排序：16

文摘

A novel nanocarrier was formed between dendrimer phthalocyanines and triblock copolymers. The intracellular uptake of Gn-DPcZn was elevated as they were incorporated into the micelles. The intracellular uptake of Gn-DPcZn was inversely correlated with the generation of DPcZn. The photocytotoxicity of Gn-DPcZn incorporated into polymeric micelles was also increased. Fuorescence microscopic result indicated that Gn-DPcZn/m localized to the mitochondria.