Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis
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- 作者：Xiaoyu Zhaoa ; Xiaojian Zhanga ; Ying Lvb ; Yuming Xuc ; Menglong Lid ; Qingxia Pana ; Yaojuan Chua ; Nan Liua ; Guang-Xian Zhange ; Guang-Xian.Zhang@jefferson.edu" class="auth_mail" title="E-mail the corresponding author ; Lin Zhua ; zhulin66zhulin@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Matrine ; Experimental autoimmune encephalomyelitis ; Multiple sclerosis ; IL-33 ; ST2
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：178
- 期：Complete
- 页码：97-104
- 全文大小：3173 K
文摘
- ass="listitem" id="list_lis0005">
- ass="label">•
ar0005">The role of IL-33/ST2 axis in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), remains controversial.
- ass="label">•
ar0010">IL-33/ST2 is highly expressed in spinal cord of EAE rats, which is inhibited by Matrine (MAT).
- ass="label">•
ar0015">Therefore, inhibition of the inflammatory IL-33/ST2 axis might be a novel mechanism underlying the effect of MAT on EAE.