Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling
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文摘

SAP97 is a novel inhibitor of Wnt-induced β-catenin transcriptional activity.

SAP97 may mediate this activity through phosphorylation of GSK3β.

Increased DISC1 expression stabilizes SAP97.

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