Neurodevelopmental origins of bipolar disorder: iPSC models
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- 作者：K. Sue O'Sheaa ; b ; oshea@umich.edu" class="auth_mail" title="E-mail the corresponding author ; Melvin G. McInnisb
- 关键词：ASD ; autism spectrum disorders ; BA ; Broadmann's area ; BDNF ; brain derived neurotrophic factor ; BP ; bipolar disorder ; C ; healthy controls ; CNS ; central nervous system ; DLPFC ; dorsolateral prefrontal cortex ; hESCs ; human embryonic stem cells ; iNs ; induced neurons ; iPSCs ; induced pluripotent stem cells ; LCLs ; lymphoblastic cell lines ; MDD ; major depressive disorder ; MGE ; medial ganglionic eminence ; NPCs ; neural progenitor cells ; ONPs ; olfactory neural precursors ; PCA ; post-coital age ; PFC ; prefront
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：63-83
- 全文大小：1242 K
文摘
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Bipolar disorder (BP) critically requires cell-based models.
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We review the data that suggest that BP has strong developmental underpinnings.
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Gene expression analyses identify developmental pathways, calcium signaling.
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Induced pluripotent stem cells offer a new opportunity to model BP.
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Early studies identify differences in neuronal differentiation and activity.