- 作者：Adriana Tarl¨¢ Lorenzi ; Jos¨¦ Humberto T.G. Fregnani ; J¨²lio C¨¦sar Possati-Resende ; Cristovam Scapulatempo Neto ; Luisa Lina Villa ; Adhemar Longatto-Filho
- 关键词：Human papillomavirus ; Cervical cancer ; Self-sampling ; Molecular test ; Screening
- 刊名：Gynecologic Oncology
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：131
- 期：1
- 页码：131-134
- 全文大小：173 K
Objective
Cervical cancer is the second most common cancer among Brazilian women. High-risk human papillomavirus (hr-HPV) persistence is the primary cause of cervical neoplasia. Early detection of hr-HPV is important for identifying women at risk for developing cervical lesions. Approximately 85 % of new cases of cervical cancer worldwide and 50 % of the total cervical cancer deaths occurred in developing countries. Here, a new methodology to support a cervical cancer screening program was evaluated in women from various Brazilian regions.Methods
Two thousand women aged 18-77 years were enrolled in an opportunistic cervical cancer screening program and were randomized into self-vaginal or health professional-guided cervical sampling groups. The Qiagen careHPV? test was performed on all samples. Pap tests were performed on all women using liquid-based cytology.
Results
Positive hr-HPV results were obtained in 12.3 % (245/2000) of women; similar rates were observed in self- or health professional-collected samples. Eighty-nine percent (1719/2000) of cervical cytologies classified as normal were negative to hr-HPV. Among the cytological samples, 36.6 % classified as ASC-US + were positive to hr-HPV, 78.8 % were LSIL and 75.0 % were HSIL.
Conclusions
Self-sampled and health professional-sampled vaginal/cervical specimens did not differ in their rates of detection of hr-HPV. Therefore, HPV DNA testing in self-sampled vaginal cells is an alternative to primary screening in low-resource settings.