Preclinical identification of vaccine induced protective correlates in human leukocyte antigen expressing transgenic mice infected with Coccidioides posadasii
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- 作者：Brady J. Hurtgena ; c ; Natalia Castro-Lopeza ; Maria del Pilar Jimé ; nez-Alzatea ; d ; Garry T. Colea ; c ; Chiung-Yu Hunga ; b ; Chiungyu.Hung@UTSA.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Coccidioides ; Coccidioidomycosis ; HLA-DR4 transgenic mice ; Fungal vaccine ; Innate and adaptive immunity
- 刊名：Vaccine
- 出版年：2016
- 出版时间：17 October 2016
- 年：2016
- 卷：34
- 期：44
- 页码：5336-5343
- 全文大小：1084 K
文摘
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HLA-DR4 mice can be used to evaluate vaccine efficacies against Valley Fever.
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Maintenance of body weight correlates with vaccine protection.
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Early expansion of Th1 and Th17 cells before 9 dpc correlate with protection.
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Persistence of adaptive immunity after 35 dpc associates with poor protection.