Increasing rates of low-risk human papillomavirus infections in patients with oral cavity squamous cell carcinoma: Association with clinical outcomes

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• 作者：Li-Ang Lee^a ; ^b ; Chung-Guei Huang^a ; ^c ; Kuo-Chien Tsao^a ; ^d ; Chun-Ta Liao^a ; ^b ; ^{liaoct@adm.cgmh.org.tw} ; Chung-Jan Kang^a ; ^b ; Kei-Ping Chang^a ; ^b ; Shiang-Fu Huang^a ; ^b ; I-How Chen^a ; ^b ; Tuan-Jen Fang^a ; ^b ; Hsueh-Yu Li^a ; ^b ; Shu-Li Yang^a ; ^d ; Li-Yu Lee^a ; ^c ; Chuen Hsueh^a ; ^c ; Tse-Ching Chen^a ; ^c ; Chien-Yu Lin^a ; ^e ; Kang-Hsing Fan^a ; ^e ; Hung-Ming Wang^a ; ^f ; Shu-Hang Ng^a ; ^g ; Yu-Liang Chang^a ; ^h ; Chyong-Huey Laiⁱ ; Shin-Ru Shih^j ; Tzu-Chen Yen^a ; ^k ; ^{yen1110@adm.cgmh.org.tw} ; ^{joan0606@gmail.com}
• 关键词：OSCC ; oral cavity squamous cell carcinoma ; HPV ; human papillomavirus ; HR-HPV ; high-risk human papillomavirus ; LR-HPV ; low-risk human papillomavirus ; DFS ; disease-free survival ; DSS ; disease-specific survival ; OS ; overall survival ; FFPE ; formalin-fixed par
• 刊名：Journal of Clinical Virology
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：57
• 期：4
• 页码：331-337
• 全文大小：1125 K

文摘

Background

Although human papillomavirus (HPV) infections have been causally linked to oral cavity squamous cell carcinoma (OSCC), the potential role of low-risk HPV (LR-HPV) types in the pathogenesis of this malignancy remains unclear.

Objectives

We sought to investigate the distribution of HPV genotypes and their prognostic significance in OSCC patients treated by radical surgery, either with or without adjuvant therapy.

Study design

We studied two non-overlapping OSCC cohorts for the periods 2005-2006 (2005 cohort, n = 204) and 2010-2011 (2010 cohort, n = 206). Paraffin-embedded tissue blocks were collected, and the HPV genotype was determined using PCR plus HPV blot tests. The primary study endpoint was the prevalence of HPV genotypes. The secondary endpoints were the 2-year therapeutic outcomes.

Results

The overall prevalence of HPV infections did not differ significantly in the two study cohorts. However, the prevalence of LR-HPV was significantly higher in the 2010 cohort than in the 2005 cohort (p = 0.002). The overall prevalence of HPV infections was not significantly associated with the 2-year outcomes. However, multivariate analysis demonstrated that LR-HPV infection was a predictor of poor 2-year disease-free survival (p = 0.036, hazard ratio [HR] = 3.1), disease-specific survival (p = 0.014, HR = 3.8), and overall survival (p = 0.016, HR = 3.2) in the subgroups of OSCC patients with poor differentiation, pN2 lymph node metastases, or extracapsular spread (n = 150).

Conclusions

LR-HPV infections may have an important role in determining the clinical outcomes of certain OSCC patients bearing specific risk factors.