Characteristics of traditional Chinese medicine usage in patients with stroke in Taiwan: A nationwide population-based study

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• 作者：Chia-Chi Chang^a ; ^b ; ¹ ; ^{cheerpachang@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yu-Chen Lee^a ; ^c ; ^d ; ¹ ; ^{d5167@mail.cmuh.org.tw" class="auth_mail" title="E-mail the corresponding author} ; Che-Chen Lin^e ; ^{a21745@mail.cmuh.org.tw" class="auth_mail" title="E-mail the corresponding author} ; Chin-Hsien Chang^f ; ^g ; ^{01399@km.eck.org.tw" class="auth_mail" title="E-mail the corresponding author} ; Cheng-Di Chiu^h ; ⁱ ; ^{cdchiu@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author} ; Li-Wei Chou^c ; ^d ; ^j ; ^k ; ^{chouliwe@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mao-Feng Sun^a ; ^c ; ^j ; ^{maofeng@mail.cmuh.org.tw" class="auth_mail" title="E-mail the corresponding author} ; Hung-Rong Yen^a ; ^b ; ^c ; ^j ; ^{hungrongyen@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bu-Yang-Huan-Wu-Tang ; Cerebrovascular accident ; National Health Insurance Research Database ; Salvia miltiorrhiza Bunge ; Stroke ; Traditional Chinese medicine
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：20 June 2016
• 年：2016
• 卷：186
• 期：Complete
• 页码：311-321
• 全文大小：472 K

文摘

Stroke has been the leading causes of death worldwide. Traditional Chinese medicine (TCM) has been used for stoke patients for thousands of years. This study aimed to investigate TCM usage and prescription patterns in stroke patients in Taiwan.

Materials and methods

We analyzed a random sample of one million individuals representing the 23 million enrollees selected from the National Health Insurance Research Database in Taiwan. Demographic characteristics, TCM usage, prescription patterns and mortality rate among stroke patients were analyzed.

Results

We identified 23,816 patients who were newly diagnosed with stroke between 2001 and 2009 by their diagnostic codes (ICD-9-CM 430–438). Among them, 4302 patients had hemorrhagic stroke while 19,514 patients had ischemic stroke. Overall, 12% of the stroke patients (n=2862) were TCM users. The median interval between stroke onset to the first TCM consultation is 12.2 months. Among the TCM users, more than half (52.7%) of the patients received both Chinese herbal remedies and acupuncture/traumatology treatment. Bu-yang-huan-wu-tang and Dan-shen (Radix Salviae Miltiorrhizae; Salvia miltiorrhiza Bunge) was the most commonly prescribed Chinese herbal formula and single herb, respectively. TCM users had a higher incidence rate ratio in myalgia, myositis, fasciitis and insomnia than non-TCM users. Mental disorders such as anxiety and depression are common in both TCM and non-TCM users. Comparing with the non-TCM users, the TCM users had a lower mortality rate (adjusted hazard ratios were 0.44 in overall stroke, 0.50 in ischemic stroke and 0.25 in hemorrhagic stroke).

Conclusion

Adjunctive TCM use may reduce the risk of mortality rate among stroke patients. Bu-yang-huan-wu-tang and Dan-shen are the most common prescribed Chinese herbal formula and single herb for stroke patients, respectively. Future study investigating the anti-inflammatory and neuroprotective efficacy of Bu-yang-huan-wu-tang and Dan-shen in stroke is warranted.