Aberrant microRNA expression pattern in myelodysplastic bone marrow cells

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• 作者：Kais Hussein ; Katharina Theophile ; Guntram Bü ; sche ; Brigitte Schlegelberger ; Gudrun Gö ; hring ; Hans Kreipe ; Oliver Bock
• 关键词：microRNA ; Expression profile ; Myelodysplastic syndrome ; MDS ; del(5q) ; − ; 7 ; +8 ; Bone marrow cells
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：34
• 期：9
• 页码：1169-1174
• 全文大小：311 K

文摘

The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n = 12) and distinct cytogenetic aberrations (n = 12).

In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), −7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS.

These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells.