Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: A novel mechanism of dexamethasone-induced hematoprotection
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- 作者：Hyongbum Kim ; Ji-Young Choi ; Jung Min Lee ; Yoon Shin Park ; Hwal Suh ; Hae-Ryong Song ; Sangmee Ahn Jo ; Inho Jo
- 关键词：Dexamethasone ; Hematopoietic stem cells ; Angiopoietin-1 ; Hematoprotection ; Bone marrow
- 刊名：FEBS Letters
- 出版年：2008
- 出版时间：15 October 2008
- 年：2008
- 卷：582
- 期：23-24
- 页码：3509-3514
- 全文大小：699 K
文摘
Angiopoietin-1 (Ang-1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang-1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)-mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang-1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex-induced hematoprotection.