SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins
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- 作者：Mi-Jeong Park1 ; 6 ; Ren Sheng2 ; 6 ; Antonina Silkov3 ; 6 ; Da-Jung Jung1 ; 6 ; Zhi-Gang Wang2 ; Yao Xin2 ; Hyunjin Kim2 ; Pallavi Thiagarajan-Rosenkranz2 ; Seohyeon Song1 ; Youngdae Yoon2 ; 7 ; Wonhee Nam1 ; Ilshin Kim4 ; Eui Kim1 ; Dong-Gyu Lee1 ; Yong Chen2 ; Indira Singaram2 ; Li Wang2 ; Myoung Ho Jang4 ; Cheol-Sang Hwang5 ; Barry Honig3 ; Sungho Ryu5 ; Justin Lorieau2 ; You-Me Kim1 ; 5 ; youmekim@postech.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Wonhwa Cho2 ; wcho@uic.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：62
- 期：1
- 页码：7-20
- 全文大小：3392 K
文摘
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SH2 domains bind lipids with high affinity and specificity
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Lipids coordinate SH2 domain-mediated protein-protein interactions
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Lipids spatiotemporally control ZAP70-signaling activities in T cells
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Lipid-binding sites of SH2 domains represent a pharmacological target