Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis
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- 作者：Katerina Kouvidia ; Aikaterini Berdiakia ; Maria Tzardia ; Evgenia Karousoub ; Alberto Passib ; Dragana Nikitovica ; George N. Tzanakakisa ; tzanakak@med.uoc.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：RHAMM ; receptor for hyaluronic acid- mediated motility ; LMWHA ; low molecular weight hyaluronan ; ERK ; extracellular signal-regulated kinase ; HMWHA ; high molecular weight hyaluronan ; APC ; adenomatous polyposis coli ; TCF ; T-cell factor ; LEF ; lymphoid enhancer factor
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1860
- 期：4
- 页码：814-824
- 全文大小：1586 K
文摘
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Hyaluronan (HA) regulates crucial cancer cell functions through interactions with its RHAMM and CD44 receptors.
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Low molecular weight HA (LMWHA) enhances RHAMM expression to increase (p ≤ 0.01) HT1080 cells' growth.
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RHAMM/β-catenin complex formation increases β-catenin intracellular pool.
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LMWHA/RHAMM actions regulate fibrosarcoma cell proliferation via a β-catenin/c-myc signaling pathway.