Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation
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- 作者：L.F. Ferrari Luiz.Ferrari@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; D. Araldi Dioneia.Araldi@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; O. Bogen Oliver.Bogen@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; J.D. Levine ; jon.levine@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ECM ; extracellular matrix ; HMWH ; high molecular weight hyaluronan ; LMWH ; low molecular weight hyaluronan ; PKA ; protein kinase A ; PKC ; protein kinase C
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：390-398
- 全文大小：782 K
文摘
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Hyaluronan modulates nociceptor function by acting on CD44 receptors.
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Different forms of hyaluronan produce distinct effects on the nociceptor.
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Carrageenan-induced hyperalgesia is partially dependent on the extracellular matrix.
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Hyperalgesia produced by CD44 receptor activation is dependent on PKA and Src.