Alkyl-substituted phenylamino derivatives of 7-nitrobenz-2-oxa-1,3-diazole as uncouplers of oxidative phosphorylation and antibacterial agents: involvement of membrane proteins in the uncoupling action

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• 作者：Yuri N. Antonenko^a ; ^{antonen@genebee.msu.ru} ; Stepan S. Denisov^a ; ^b ; Ljudmila S. Khailova^a ; Pavel A. Nazarov^a ; Tatyana Rokitskaya^a ; Vadim N. Tashlitsky^b ; Alexander M. Firsov^a ; Galina A. Korshunova^a ; Elena A. Kotova^a ; ^{kotova@genebee.msu.ru}
• 关键词：NBD ; 7-nitrobenz-2-oxa-1 ; 3-diazole ; NBD-Cl ; 4-chloro-7-nitrobenz-2-oxa-1 ; 3-diazole ; Alkyl-NBD ; 4-alkylamino derivatives of 7-nitrobenz-2-oxa-1 ; 3-diazole ; NBD-Cn ; 4-alkylamino derivatives of 7-nitrobenz-2-oxa-1 ; 3-diazole with n hydrocarbon units ; NBD-C8 ; 4-octylamino-7-nitrobenz-2-oxa-1 ; 3-diazole ; Aryl-NBD ; 4-arylamino derivatives of 7-nitrobenz-2-oxa-1 ; 3-diazole ; Phenyl-NBD ; 4-phenylamino-7-nitrobenz-2-oxa-1 ; 3-diazole ; C1-phenyl-NBD ; 4-(p-tolyl)amino-7-nitrobenz-2-oxa-1 ; 3-diazole ; C4-phenyl-NBD
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1859
• 期：3
• 页码：377-387
• 全文大小：840 K
• 卷排序：1859

文摘

Cn-phenylamino 7-nitrobenz-2-oxa-1,3-diazole (Cn-phenyl-NBD) varied in Cn alkyl chain Cn-phenyl-NBD with n = 1, 4, 6 carried protons across planar BLM with increasing efficacy C6-phenyl-NBD accelerated respiration and lowered membrane potential of mitochondria C6- and C4-phenyl-NBD suppressed membrane potential and growth of Bacillus subtilis