Alkyl-substituted phenylamino derivatives of 7-nitrobenz-2-oxa-1,3-diazole as uncouplers of oxidative phosphorylation and antibacterial agents: involvement of membrane proteins in the uncoupling action
文摘
Cn-phenylamino 7-nitrobenz-2-oxa-1,3-diazole (Cn-phenyl-NBD) varied in Cn alkyl chain Cn-phenyl-NBD with n = 1, 4, 6 carried protons across planar BLM with increasing efficacy C6-phenyl-NBD accelerated respiration and lowered membrane potential of mitochondria C6- and C4-phenyl-NBD suppressed membrane potential and growth of Bacillus subtilis