Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion
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- 作者：Noelia Mireta ; noeliamiret@hotmail.com.ar" class="auth_mail" title="E-mail the corresponding author ; Carolina Pontilloa ; caroponti@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Clara Venturab ; clara.ventura.lp@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Alejandro Carozzoc ; ale.carozzo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Florencia Chiappinia ; florenciachiappini@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Diana Kleiman de Pisareva ; dianakleiman@yahoo.com.ar" class="auth_mail" title="E-mail the corresponding author ; Natalia Ferná ; ndezc ; natycfernandez@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Claudia Coccab ; cm_cocca@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Andrea Randia ; andybiol@yahoo.com.ar" class="auth_mail" title="E-mail the corresponding author ; andyrandi15@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AhR ; aryl hydrocarbon receptor ; ANF ; α-naphthoflavone ; EMT ; epithelial-mesenchymal transition ; ERα ; estrogen receptor α ; ERK1/2 ; extracellular signal related kinase 1 and 2 ; HCB ; hexachlorobenzene ; JNK ; c-jun n-terminal kinase ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TGF-β1 ; transforming growth factor-β1 ; TβRI ; type I TGF-β receptor ; TβRII ; type II TGF-β receptor
- 刊名：Toxicology
- 出版年：2016
- 出版时间：29 July 2016
- 年：2016
- 卷：366-367
- 期：Complete
- 页码：20-31
- 全文大小：2860 K
文摘
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HCB enhances TGF-β1 expression and activation levels in breast cancer cells.
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HCB activates TGF-β1 pathways: Smad3, JNK and p38.
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The HCB- induced migration and invasion involves TGF-β1 signaling pathways.
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HCB modulates AhR levels and activation.
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HCB enhances TGF-β1 mRNA expression in an AhR-dependent manner.