Quantitative determination of hydroxy polycylic aromatic hydrocarbons as a biomarker of exposure to carcinogenic polycyclic aromatic hydrocarbons
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- 作者：Million B. Woudneha ; mwoudneh@axys.com" class="auth_mail" title="E-mail the corresponding author ; mwoudneh@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jonathan P. Benskina ; Richard Gracea ; M.Coreen Hamiltona ; Brian H. Mageeb ; Glenn C. Hoegerc ; Norman D. Forsbergb ; John R. Cosgrovea
- 关键词：Biomonitoring ; OH-PAHs ; Stability ; Antioxidants ; GC&ndash ; HRMS ; Urine
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：8 July 2016
- 年：2016
- 卷：1454
- 期：Complete
- 页码：93-100
- 全文大小：1170 K
文摘
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A new HRGC–HRMS method was developed for determination of 4 OH-PAHs.
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The causes of OH-PAHs instability were identified as photo induced oxidation.
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The current method controlled OH-PAH analyte degradation during analysis.
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Conjugated OH-PAHs are more stable than non-conjugated OH-PAHs.
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Accuracy and precision were 77.4–117% (<15% RSD) in synthetic and human urine samples.