Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice
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- 作者：Jeffery A. Boychuka ; b ; c ; Corwin R. Butlera ; Katalin Cs. Halmosa ; Bret N. Smitha ; b ; d ; bret.smith@uky.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：GABA ; gamma-aminobutyric acid ; ITonicGABA ; tonic GABA current ; GABAAR ; type A GABA receptor ; CCI ; controlled cortical impact ; DG ; dentate gyrus ; TBI ; traumatic brain injury ; DGC ; dentate granule cell ; THIP ; 4 ; 5 ; 6 ; 7-tetrahydroisoxazolo[5 ; 4-c]pyridine-3-ol hydrochloride ; L655 ; 708 ; 11 ; 12 ; 13 ; 13a-Tetrahydro-7-methoxy-9-oxo-9 ; H-imidazo[1 ; 5-a]pyrrolo[2 ; 1-c][1 ; 4]benzodiazepine-1-carboxylic acid ; ethyl ester ; THDOC ; 3α ; 21-Dihydroxy-5α&ndash ; pregnan-20-one ; qRT-PCR ; quantitative real-time polymerase
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：178-189
- 全文大小：1231 K
文摘
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GABAAR currents in DGCs contralateral to CCI are unchanged after brain injury.
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Resting tonic GABAAR currents are unchanged in DGCs ipsilateral to CCI injury.
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THIP and THDOC-evoked tonic GABAAR currents are reduced in injured DGCs.
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20">L655,708-evoked tonic GABAAR currents are unchanged in injured DGCs.
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25">Gene expression of GABAAR α4, α5 and δ subunits is unchanged in injured DG.