Synthesis of pH-sensitive amphiphilic doxorubicin conjugate, F127-CS-DOX for co-delivery of doxorubicin and paclitaxel.
The investigation of properties of polymeric micelles self-assembled by F127-CS-DOX as well as encapsulating paclitaxel physically.
Evaluation of the pH-dependent release behaviors and in vivo pharmacokinetic study of two chemotherapeutic drugs loaded in the micelles.