pH-sensitive polymeric micelles formed by doxorubicin conjugated prodrugs for co-delivery of doxorubicin and paclitaxel
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- 作者：Yakun Ma1 ; Xiaohui Fan1 ; Lingbing Li ; cnlilingbing@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan (PubChem CID ; 3086191) ; Pluronic F127 (PubChem CID ; 24751) ; Doxorubicin hydrochloride (PubChem CID ; 443939) ; Paclitaxel (PubChem CID ; 36314) ; cis-Aconitic anhydride (PubChem CID ; 65163) ; Succinic anhydride (PubChem CID ; 7922) ; 2 ; 4 ; 6-Trinitrobenzenesulfonic acid (PubChem CID ; 11045) ; N-hydroxysuccinimide (PubChem CID ; 80170) ; 4-Dimethylaminopyridine (PubChem CID ; 14284) ; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (PubChem CID ; 2723939)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：10 February 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：19-29
- 全文大小：2313 K
文摘
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Synthesis of pH-sensitive amphiphilic doxorubicin conjugate, F127-CS-DOX for co-delivery of doxorubicin and paclitaxel.
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The investigation of properties of polymeric micelles self-assembled by F127-CS-DOX as well as encapsulating paclitaxel physically.
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Evaluation of the pH-dependent release behaviors and in vivo pharmacokinetic study of two chemotherapeutic drugs loaded in the micelles.