文摘
Corticosteroids prodrugs have been synthesized by adopting Steglich reaction. Compounds were characterized with the help of 1H, 13C NMR, FT-IR and ESI-MS. From first hyperpolarizability, 4 (β0 = 5.66 × 10−30 esu) shows good NLO material. From global reactivity descriptors, compound 7 (ω = 2.81) act as good electrophile. Molecular electrostatic potential surface helps to determine probable reaction path.