A tryptic hydrolysate from bovine milk αs1-casein enhances pentobarbital-induced sleep in mice via the GABAA receptor
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- 作者：Irene Joy I. dela Peñ ; aa ; Hee Jin Kima ; June Bryan de la Peñ ; aa ; Mikyung Kima ; Chrislean Jun Botanasa ; Kyung Yi Youa ; Taeseon Wooa ; Yong Soo Leeb ; Jae-Chul Jungc ; Kyung-Mi Kimc ; Jae Hoon Cheonga ; cheongjh@syu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bovine αS1-casein tryptic hydrolysate (CH) ; Alpha-casozepine ; Casein ; Milk ; Sleep ; Benzodiazepine ; Pentobarbital ; EEG
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：313
- 期：Complete
- 页码：184-190
- 全文大小：1515 K
文摘
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Bovine αS1-casein tryptic hydrolysate did not alter the locomotor activity and motor function of mice.
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Bovine αS1-casein tryptic hydrolysate potentiated the sleep induced by pentobarbital sodium in mice.
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Bovine αS1-casein tryptic hydrolysate increased the slow (delta) EEG wave in rats.
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Bovine αS1-casein tryptic hydrolysate increased Cl− influx, in vitro, which was blocked by bicuculline.
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Bovine αS1-casein tryptic hydrolysate has sleep-promoting properties with no or minimal sedative effects.