Isolation and absolute configurations of diastereomers of 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol from Chimonanthus salicifolius
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- 作者：Dan Lia ; Yu-Yan Jianga ; Zhi-Min Jinb ; Hai-Yan Lic ; Hu-Jun Xiea ; Bin Wud ; Kui-Wu Wanga ; wkwnpc@zjgsu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chimonanthus salicifolius ; Calycanthaceae ; 8α-Hydroxy-T-muurolol ; (1α ; 6β ; 7β)-Cadinane-4-en-8α ; 10α-diol ; Sesquiterpene ; Bioactivity
- 刊名：Phytochemistry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：294-300
- 全文大小：992 K
文摘
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8α-Hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol were isolated from Chimonanthus salicifolius.
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Their structures were established by 1D, 2D NMR and HR-MS spectroscopic analyses.
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Their absolute configurations were achieved by X-ray crystallography investigations.
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Both compounds showed immunosuppressive activities in a dose-dependent manner.