Relationship between chromatographic resolution and amide structure of chiral 2-hydroxy acids as O-(−)-menthoxycarbonylated diastereomeric derivatives for enantiomeric separation on achiral gas chromatography
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- 作者：Eunju Chaa ; b ; Sohee Kima ; Kang Mi Leea ; Ho Jun Kima ; Ki Hun Kima ; Oh-Seung Kwona ; Ki Duk Parkc ; Jaeick Leea ; jaeicklee@kist.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Enantiomeric separation ; 2-Hydroxy acids ; (&minus ; )-Menthoxycarbonylated tert-butylamides
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：1012-1013
- 期：Complete
- 页码：17-22
- 全文大小：1435 K
文摘
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The enantiomeric separation method of chiral 2-hydroxy acids was developed.
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O-(−)-menthoxycarbonylated tert-butylamide derivatives were the best diastereomeric conformations.
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The conformational rigidity can have stronger effects on resolution than the distance between chiral centers.
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Elution order was affected by the number of substituents attached to nitrogen atom of the amine.