Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion
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- 作者：Kenta Kagayaa ; b ; Atsushi Sasakib ; Yurika Kinob ; Hiroyuki Taniguchic ; Yasushi Kuraishia ; 1 ; Tsugunobu Andoha ; andoht@pha.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-HNE ; 4-hydroxy-2-noneal ; H2O2 ; hydrogen peroxide ; NAC ; N-acetyl-l-cysteine ; PVDF ; polyvinylidene difluoride ; ROS ; reactive oxygen species ; SEM ; standard error of the mean
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：19 September 2016
- 年：2016
- 卷：631
- 期：Complete
- 页码：109-114
- 全文大小：652 K
文摘
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Transient ischemia-reperfusion in the hand and foot elicits spontaneous dysesthesia.
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We established a mouse model of hind-paw transient ischemic-reperfusion.
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In this model, peripheral nerve activity and lipid peroxidation were increased.
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20">An antioxidant reagent countered both the nerve activity and lipid peroxidation.
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25">Both oxidative stress and nerve activity may contribute to peripheral dysesthesia.