Structural features of palladium(II) complexes with ¦Á-hydroxycarboxylate and aromatic ¦Á,¦Á¡ä-diimine ligands

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• 作者：Susana Balboa^a ; Rosa Carballo^b ; Alfonso Castiñ ; eiras^a ; ^{alfonso.castineiras@usc.es} ; Josefa Marí ; a Gonzá ; lez-Pé ; rez^c ; Juan Nicló ; s-Gutié ; rrez^c
• 关键词：Palladium complexes ; ¦Á-Hydroxycarboxylates ; Aromatic ¦Á ; ¦Á&prime ; -diimines ; Crystal structure analysis ; Cytotoxic activity
• 刊名：Polyhedron
• 出版年：2013
• 出版时间：13 February, 2013
• 年：2013
• 卷：50
• 期：1
• 页码：512-523
• 全文大小：1330 K

文摘

The neutral ¦Á-hydroxycarboxylate complexes [Pd(bpy)(GLYO)]¡¤3H₂O (1), [Pd(bpy)(MANO)]¡¤4H₂O (2) and [Pd(GLYO)(phen)]¡¤5H₂O (3), together with the palladium(II) complexes [Pd(phen)₂](NO₃)₂ (4) and [Pd(CH₂COCH₃)(bpy)(Cl)] (5) (where GLYO and MANO are the glycolate and mandelate dianions, respectively, and bpy and phen, 2,2¡ä-bipyridine and 1,10-phenantrholine, respectively), have been prepared by reaction of [Pd(bpy)Cl₂] or [PdI₂(phen)] with salts of ¦Á-hydroxycarboxylic acids in water. These compounds were characterized by elemental analysis, mass spectrometry, ¹H and ¹³C NMR, UV-Vis, IR spectroscopy, TG analysis and single crystal X-ray diffraction. The aforementioned studies confirmed the formation of a variety of square-planar mononuclear compounds (1-3) where the ¦Á,¦Á¡ä-diimine ligands exhibit a rather simple bidentate chelating role and the ¦Á-hydroxycarboxylate ligands are dianionic. A variety of ligand distortions, hydrogen-bonding and stacking interactions were found and these were thoroughly analyzed. In compounds 1 and 3, the complex molecules are stacked in such a way that the coordination planes are parallel to one another. The Pd?Pd distances between the nearest stacked neighbors are 3.8043(6) and 3.302(2)/3.475(1) ?, respectively. Compounds 1-3 have been tested in vitro for cytotoxicity on HeLa-299 human tumor cell lines.