27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells
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- 作者：Li-Ming Ma mliming_gz@163.com" class="auth_mail" title="E-mail the corresponding author ; Zi-Rui Liang liangzr@mail2.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ke-Ren Zhou zhoukr@mail2.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hui Zhou lsszh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liang-Hu Qu ; lssqlh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; 27-Hydroxycholesterol ; Myc protein stability ; PP2A ; SCP1 ; FBW7
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 November 2016
- 年：2016
- 卷：480
- 期：3
- 页码：328-333
- 全文大小：783 K
文摘
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27-Hydroxycholesterol (27-HC) activates Myc via increasing its protein stability.
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27-HC inhibits PP2A and SCP1 transcription to block pS62-Myc dephosphorylation.
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20">27-HC suppresses FBW7 transcription to prevent pT58-Myc degradation.